Cellular morphology of a cytological preparation is distorted when smears are:

Cellular morphology in cytological preparations is crucial for accurate diagnosis, as it allows for the assessment of cell shape, size, and arrangement. When a smear is allowed to dry prior to staining, the cellular structure can become distorted due to the evaporation of water and changes in the cell's physical properties. This drying process can lead to artifacts that obscure true morphological features, making it difficult to interpret the cells accurately under the microscope.

Inadequate fixation, prolonged exposure to staining solutions, or extended time in clearing solutions can also affect cellular morphology. However, it is the drying of the smear that has the most immediate and detrimental impact on preserving the delicate features of the cells, leading to an inaccurate representation of their true morphology. This is why ensuring that smears are properly handled and not dried out is essential in cytological preparations.